Tools
Below are software tools and databases developed by members of the lab. We hope you find these useful!
If you have any questions or suggestions, please don’t hesitate to reach out to us.
A simulation framework for eukaryotic pangenomes. PansimNuc models mutation, selection, gene and Transposable Element (TE) gain/loss and mobility, recombination and demography. PansimNuc generates simulated genomes that can be used to benchmark pangenome analysis tools and methods, and will be used to study the interaction of a multitude of neutral and selective forces that shape fungal pangenomes. It also comes with a suite of helper tools to analyse simulated populations.
Earl Grey is a fully automated transposable element (TE) annotation pipeline that combines widely-used repeat detection tools with a consensus elongation process to produce high-quality, de novo TE annotations for new genome assemblies. Packaged via Bioconda and Docker for easy deployment on any system.
EarlGrey ParTEA is a Snakemake-based pipeline that extends Earl Grey to process multiple genomes in parallel, building pangenome TE libraries and enabling comparative transposable element analysis across species or populations. It supports SLURM cluster submission and automated resource allocation.
MycoMobilome is a non-redundant database of transposable element consensus sequences generated from over 4,000 publicly available fungal genome assemblies, providing a comprehensive and reproducible reference for fungal TE annotation and comparative studies. Community contributions are welcome via the Zenodo MycoMobilome community.
genomepanel_nf is a Nextflow pipeline for highly efficient reference genome mapping, variant (SNP/indel) calling and quality control of large genome panels, accepting local FASTQ files, SRA/ENA accessions, or pre-processed BAM files as input. It performs joint genotyping via GATK best practices and runs fully containerised via Singularity on HPC or local machines.